The Cross of Santo Domingo is a large cross made from gold and gemstones from the goldmine in El Dorado. The cross was commissioned by Spanish conquistadores for Spain and was being brought on their vessel back to Europe. As the vessel sank, the Cross of Santo Domingo was saved by the crew onboard the Royal Merchant on order by Captain Limbrey. As the Royal Merchant sank outside Outer Banks, Denmark Tanny brought the cross ashore and hid it in The Freeman Church. The Cross of Santo Domingo was encased in wood and camouflaged as one of the ceiling beams.
The Cross of Santo Domingo is forgotten as the church is abandoned but is eventually discovered by the Pogues after following several clues left by Denmark Tanny. But when they are forced to leave the cross, Rafe Cameron and Renfield take it to Carla Limbrey. After Renfield's death Rafe brings the Cross of Santo Domingo to Tannyhill and then on The Coastal Venture. The Pogues tries to steal the Cross of Santo Domingo from onboard the boat but fail. Pope then tries to dump it in the ocean, but the cross is saved by Rafe. The Camerons bring the Cross of Santo Domingo to their island, but Ward starts to doubt himself and decides he wants to donate the Cross of Santo Domingo to a museum in the US as a way to atone for his sins. Rafe, however, protests and claims he has ownership of the Cross of Santo Domingo. When Ward tries to ship the Cross of Santo Domingo, both the Pogues and Rafe intend to intercept it. After a daring chase, the Pogues get away with the box marked with the shipment information of the cross, only to find out that Rafe and Barry have beaten them too it.
Rafe and Barry decide to melt the Cross of Santo Domingo in order to sell the gold and gems. In a homemade oven in Barry’s backyard, the Cross of Santo Domingo is melted down.
Added to the lore in season 4, Rafe claims the cross was not made of solid gold but only gold plated.